Joseph B Domachowske Selected Research

Pneumovirus Infections

1/2016	Signaling via pattern recognition receptors NOD2 and TLR2 contributes to immunomodulatory control of lethal pneumovirus infection.
2/2012	IL-21 promotes the pathologic immune response to pneumovirus infection.
1/2010	Granzyme A- and B-cluster deficiency delays acute lung injury in pneumovirus-infected mice.
1/2009	Mechanical ventilation enhances lung inflammation and caspase activity in a model of mouse pneumovirus infection.
2/2006	Ribavirin and cysteinyl leukotriene-1 receptor blockade as treatment for severe bronchiolitis.
8/2004	Functional antagonism of chemokine receptor CCR1 reduces mortality in acute pneumovirus infection in vivo.
4/2004	Animal pneumoviruses: molecular genetics and pathogenesis.
8/2003	Diminished expression of an antiviral ribonuclease in response to pneumovirus infection in vivo.
1/2003	Altered pathogenesis of severe pneumovirus infection in response to combined antiviral and specific immunomodulatory agents.
7/2002	Differential expression of proinflammatory cytokine genes in vivo in response to pathogenic and nonpathogenic pneumovirus infections.

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Joseph B Domachowske Research Topics

Disease

23	Infections 01/2016 - 06/2002
10	Virus Diseases (Viral Diseases) 01/2016 - 01/2003
10	Pneumovirus Infections 01/2016 - 07/2002
9	Inflammation (Inflammations) 01/2016 - 07/2002
6	Human Influenza (Influenza) 03/2017 - 06/2013
4	Whooping Cough (Pertussis) 01/2018 - 01/2015
3	Neoplasms (Cancer) 01/2021 - 01/2016
3	Pneumonia (Pneumonitis) 01/2020 - 01/2009
3	Weight Loss (Weight Reduction) 11/2014 - 01/2007
3	Asthma (Bronchial Asthma) 01/2014 - 06/2002
2	Lung Diseases (Lung Disease) 12/2013 - 06/2004
2	Respiratory Syncytial Virus Infections 12/2013 - 07/2009
2	Hypersensitivity (Allergy) 07/2009 - 01/2009
2	Bronchiolitis 02/2006 - 01/2005
1	COVID-19 01/2022
1	Necrotizing Pneumonia 01/2020
1	Respiratory Tract Infections (Respiratory Tract Infection) 01/2020
1	Lemierre Syndrome 01/2020
1	Fever (Fevers) 03/2017
1	Porcine Reproductive and Respiratory Syndrome (PRRS) 01/2016
1	Autistic Disorder (Autism) 11/2015
1	Tetanus 04/2015
1	Diphtheria 04/2015
1	Meningococcal Infections 03/2014
1	Bronchopulmonary Dysplasia 11/2012
1	Autoimmune Diseases (Autoimmune Disease) 02/2012
1	Paramyxoviridae Infections (Parainfluenza) 04/2010
1	Acute Lung Injury 01/2010
1	Adenoviridae Infections (Adenovirus Infections) 05/2009
1	Respiratory Sounds (Crackle) 01/2009
1	Enterobiasis 05/2008
1	Viral Bronchiolitis 05/2006
1	Strongyloidiasis 05/2006
1	Schistosomiasis (Bilharziasis) 05/2006

Drug/Important Bio-Agent (IBA)

15	VaccinesIBA 01/2022 - 01/2011
13	Antiviral Agents (Antivirals)IBA 01/2014 - 07/2002
7	CytokinesIBA 01/2014 - 07/2002
6	AntigensIBA 03/2017 - 02/2010
4	Papillomavirus Vaccines (HPV Vaccines)IBA 01/2021 - 11/2015
4	Influenza Vaccines (Influenza Vaccine)FDA Link 06/2016 - 06/2013
3	InterferonsIBA 12/2013 - 07/2002
3	Chemokine CCL3IBA 03/2009 - 01/2003
2	Hemagglutinins (Hemagglutinin)IBA 03/2017 - 06/2016
2	Pattern Recognition ReceptorsIBA 01/2016 - 09/2015
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2013 - 06/2007
2	Biomarkers (Surrogate Marker)IBA 12/2013 - 04/2010
2	Proteins (Proteins, Gene)FDA Link 02/2012 - 07/2002
2	AllergensIBA 02/2010 - 06/2002
2	Interleukin-5 (Interleukin 5)IBA 07/2009 - 06/2002
2	Formaldehyde (Formol)FDA Link 07/2009 - 07/2009
2	Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)IBA 06/2007 - 08/2004
2	ChemokinesIBA 05/2006 - 07/2002
2	Ribavirin (Virazole)FDA LinkGeneric 02/2006 - 01/2003
2	Ribonucleases (Ribonuclease)IBA 10/2005 - 08/2003
1	BNT162 VaccineIBA 01/2022
1	nirsevimabIBA 01/2020
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2020
1	Nicotine FDA Link 01/2020
1	Tetanus Toxoid (Vaccine, Tetanus)FDA Link 01/2018
1	Diphtheria Toxoid (Vaccine, Diphtheria)FDA Link 01/2018
1	LigandsIBA 01/2016
1	Meningococcal Vaccines (Meningococcal Vaccine)IBA 04/2015
1	Pertussis VaccineIBA 01/2015
1	Ligases (Synthetase)IBA 11/2014
1	Interferon Type IIBA 11/2014
1	Interferon-gamma (Interferon, gamma)IBA 11/2014
1	2',5'-oligoadenylate (PAPAPA)IBA 11/2014
1	Conjugate VaccinesIBA 03/2014
1	MenACWYIBA 03/2014
1	OvalbuminIBA 01/2014
1	Interleukin-6 (Interleukin 6)IBA 12/2013
1	InterleukinsIBA 12/2013
1	Chemokine CXCL1IBA 02/2012
1	interleukin-21 (interleukin 21)IBA 02/2012
1	Interleukin-21 ReceptorsIBA 02/2012
1	AntibodiesIBA 07/2011
1	Interleukin-4 Receptors (Interleukin 4 Receptor)IBA 02/2010
1	Granzymes (Granzyme)IBA 01/2010
1	Caspase 3 (Caspase-3)IBA 01/2010
1	Interleukin-13IBA 07/2009
1	Respiratory Syncytial Virus VaccinesIBA 07/2009
1	CCR1 ReceptorsIBA 03/2009
1	Viral VaccinesIBA 01/2009
1	CaspasesIBA 01/2009
1	Interleukin-8 (Interleukin 8)IBA 06/2007
1	Interferon-betaIBA 06/2007
1	Neutralizing AntibodiesIBA 01/2007
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 10/2006
1	Transaminases (Aminotransferases)IBA 10/2006
1	Alanine Transaminase (SGPT)IBA 10/2006
1	Praziquantel (Biltricide)FDA Link 05/2006
1	Ivermectin (Mectizan)FDA Link 05/2006
1	Albendazole (Albenza)FDA Link 05/2006
1	LeukotrienesIBA 02/2006
1	Chemokine CCL17IBA 10/2005
1	Interferon alpha-beta Receptor (Receptor, Interferon alpha beta)IBA 10/2005
1	Chemokine CCL24IBA 10/2005

Therapy/Procedure

7	Therapeutics 01/2011 - 04/2004
1	Length of Stay 11/2012
1	Artificial Respiration (Mechanical Ventilation) 01/2009